Design and purpose of the project
Establishing a multi-center basis for future therapeutic interventions in human spinal cord injury (EMSCI)
Internationale Stiftung für Forschung in Paraplegie , Zürich
Patients with acute traumatic spinal cord injury will be tested and documented within a fixed time schadule(acute, 4, 12, 24 and 48 weeks) after spinal cord injury and must comply with clearly defined incusion criteria. The examinations consist of a standard set of neurological, neurophysiological and functional assessments. The collected data from each center is sent to the coordinating center (Zurich) in regulary time intervals to be joined into a central database.
SPIDI - SPInal cord Diagnostic Improvement study
Our department joined another cooperating centres in the EMSCI project and participated in prospective study concerning prognostic value of MRI for the evaluation of traumatic SCI.
The purpose of this study was to quantify traumatic SCI. The hypothesis was, that patients with severe primary SCI do not benefit from decompression and/or neuroprotective measurements. Patients with mild primary SCI do benefit from decompression and/or neuroprotective measurements.
The hypothesis of this study was, that biomarkers are quantitative method for measuring traumatic SCI. The purpose of this study was to measure the concentrations of GFAp, MBP, Tau, S-100beta , NSE and NFL in CSF in patients with SCI of the cervical or thoracic spine.
In total over 1000 patients (August 2006) with spinal cord injury are included in the EMSCI database. Several publications have emerged by the member hospitals of the project. Finally a new network EUCTN (European clinical trials network) has been founded to serve as contact for industrial clinical trials.
Dysfunction of the respiratory system in patients after spinal cord injury (SCI)
This project started at 2010, anticipated end is at 2015. The expected result of the project is a selection of the most valid PFT parameters improving both early detection and a development of specific respiratory complications during early and late course after SCI. We will define specific combinations of PFT abnormalities, which differ with respect to neurologic level of SCI and/or a its severity (according to the ASIA impairment scale). Implementation of new diagnostic approaches will refine on a prediction of respiratory complications after SCI.