Credit for the establishment of our clinic belongs to doc. MUDr. Karel Šilink, DrSc., who was a student of the founder of Czech endocrinology, academic prof. Josef Charvát, DrSc. The department was opened on July 1, 1959 and functioned as a detached hospitalization base for the Endocrinological Research Institute (VÚE) founded by Mr.Šilink.
doc. MUDr. Karel Šilink, DrSc.
First years of the clinic
Initially, doctors fully used the capacity of twenty hospital beds for the purposes of diagnosis, and after January 1960 also for treatment by means of bare sources. The focal point of the work of the inpatient department consisted mainly in the treatment of thyreotoxicosis (a disease involving excessive amounts of thyroid hormones in the blood). Two years later our department obtained a Siemens scintigraph, and we were able to extend our services to include consulting examinations for the City Hospital in Motol. In addition, we partially incorporated into the structures of this hospital a collaborative department of internal medicine.
Treatment prior to the age of cytostatics
This department involved about 30 employees from the Endocrinological Research Institute and the Motol Hospital and was led by chief doctor MUDr. Jan Kubal. The doctors treated approximately 400 patients per year in the out-patient and in-patient departments. By the time the age of cytostatics arrived in 1973, we had already treated, in cooperation with the gynecological department, about 200 female patients through intracavernous application of a colloid of radioactive gold, Au.
„Hot“ operations on thyroid tumors
Working closely with the excellent thyroid surgeon prof. MUDr. B. Niederle, DrSc., head of the surgical department, enabled us to introduce so-called „hot“ operations on the thyroid after the application of radioactive iodines.
Treatment of follicular and dendritic cancer
Since 1965, the department of radioisotopes has been led by chief doctor MUDr. Jan Němec, CSc. At that time, treatment of differentiated follicular and dendritic cancer of the thyroid became the main area of focus for our doctors. Our clinic has continued along this line until today.
prof. MUDr. Jan Němec, DrSc.
Extending the capacity of the clinic
Between 1972 and 1974 we were able to develop our diagnosis and treatment thanks to the commissioning of a color scintigraph. At the same time, our workplace grew to include another pavilion, where the diagnostic part of the department of radioisotopes was transferred. This allowed the capacity of hospital beds to be increased to 25 and then, after yet another reconstruction in 1980, to the final number of 29 hospital beds.
Specialized guidance center
The specialized guidance center for the treatment of serious forms of endocrinological orbitopathy was founded in 1970 and led by MUDr. Stanislav Váňa, CSc. He laid the foundations for the emergence of interdisciplinary cooperation between an endocrinologist and ophthalmologist in one medical office.
Treatment of acinuous cancer
In addition to treatment and preventative examinations of patients with dendritic and follicular cancer of the thyroid, in 1978 our clinic also became a national center for caring for patients with acinuous malignant cancer of the thyroid. At that time we treated people from Bohemia as well as a large part of Slovakia, and our workplace was led by MUDr. Marta Neradilová, CSc.
Establishment of the Department of Nuclear Medicine
When the City Hospital Motol transformed into University Hospital Motol in 1985, a Department of Nuclear Medicine was founded at this hospital. In 1992 this department, along with the inpatient part of the Endocrinological Research Institute, formed the basis for the newly-formed Clinic of Nuclear Medicine – a common workplace of the 2nd Faculty of Medicine of Charles University and University Hospital Motol. And the same year doc. MUDr. Jan Němec DrSc. became its first head.
New premises and modern equipment
A fundamental change for the Clinic took place in March 1998, when it moved into new premises at the blue pavilion in the University Hospital Motol. On account of this move, we obtained modern instrumental equipment and premises worthy of a workplace of national importance. These changes enabled us to further develop nuclear diagnosis, in particular, and extend it to include a number of special radionuclide examinations. Treatment methods for non-thyroidal diseases were also being developed. The same year, our Radioimmunoanalytic Laboratory became a part of the Institute of Clinical Biochemistry of the 2nd Faculty of Medicine of Charles University and University Hospital Motol.
Further development of diagnoses
In 1999 prof. Němec was replaced by MUDr. Petr Vlček, CSc in the position of the head of the clinic. Basic diagnostic and treatment programs have been developed, cooperation with other clinics has been extended, and there has been a continuation in the bountiful scientific-research and pedagogical activities under his management.
Currently there are approx. 60 employees working at out clinic. Our register contains 45000 patients; 11300 people with differentiated malignant cancer of the thyroid were being treated at our clinic by the end of 2010 (which is one of the largest groups of its kind in the world). Our in-patient department hospitalizes 950 patients (95% of whom have cancer) annually. Doctors in our outpatient endocrinological department examine around 13000 patients per year, and our nuclear medicine out-patient department – around 6000 patients per year.
Research activities and new treatment procedures
Our research activities are closely linked to the clinical practice. We introduced scintigraphic diagnosis using 99mTc-MIBI into standard examinations during 1990s. We performed the first I-MIBG treatment on patients with modular thyroidal cancer in 1994. Three years later in collaboration with the Clinic of Child Oncology of the 2nd Faculty of Medicine of Charles University, we introduced this treatment for children with malignant neuroblastoma; later in 1999 – for children with malignant cancer and in 2001 – for children with malignant feochromocytoma.
Center for Thyroidal Oncology and Thyroidal Orbitopathy
Director of University Hospital Motol decided to establish the Center for Thyroidal Oncology and Thyroidal Orbitopathy of the 2nd Faculty of Medicine of Charles University and University Hospital Motol in 2001. This center was led by doc. Vlček from the very beginning. It provides expert guidance care all over Czech Republic.
Our clinic was renamed (in accordance with its treatment-preventative activities and focus on undergraduate and post-graduate study) into Clinic of Nuclear Medicine and Endocrinology of the 2nd Faculty of Medicine of Charles University and University Hospital Motol (KNME) by Minister of Health of the Czech Republic decision in 2002.
We are allowed to use radioactive pharmaceuticals treatment
Our clinic has been a certified center for treatment of oncological diseases using the radioactive pharmaceutical I-MIBG, for diagnosis and treatment after preparation by means of the human recombinant thyreo-stimulating hormone (rhTSH), and for treatment of serious thyroidal autoimmune orbitopathy (TAO) as an analogy to somatostatin since 2008.